We found that fibroblasts served as the sensitively infected cells in substantia propria of cornea and the mair site of multiplication of HSV-1. The principal pathogenic factor was the decomposition of fibroblasts after infection. 发现角膜固有层中的成纤维细胞是易感细胞,是HSV-1繁殖的主要场所,致病的根本原因是病毒感染后成纤维细胞受到裂解破坏。